Fifth Disease(Erythema Infectiosum)

The fifth disease or Erythema infectiosum is caused by a virus called Parvovirus B19. The fifth disease is most common in children between 5 and 15 years old and begins with a low-grade fever, headache, and mild cold-like symptoms. A few days later, a bright red rash develops on the face giving a “slapped-cheek” appearance. The “net-like or lacy” rash then spreads to the trunk, arms, and legs. It may take up to 3 weeks for the rash to completely clear. In the meantime, exposure to sunlight, heat, exercise, and stress may worsen the rash. Rarely, mostly in older kids and adults, the Parvovirus infection may cause hand, wrist, knee, and ankle joint swelling or pain.

Is the fifth disease serious?

The vast majority of people who develop the Fifth disease get over the infection without any consequences or complications. However, children with weakened immune systems (i.e. AIDS) or certain blood disorders (i.e. sickle cell anemia) may become quite ill. Also, Parvovirus B19 infection during pregnancy may cause problems for the unborn child, especially if the infection occurs during the first half of the pregnancy. Fortunately, about 50% of all pregnant women are immune or protected from having had a previous infection with Parvovirus. Serious problems occur in less than 5% of women who become infected during pregnancy. Female teachers and child caregivers of childbearing age should be aware of this potential complication. Pregnant women who develop a rash or have been exposed to someone with the Fifth disease should call their obstetrician.

Making the diagnosis

Making the diagnosis of the fifth disease is usually made upon recognizing the characteristic rash a child develops. Specific blood tests are also available to determine if a child is infected by the Parvovirus. These same tests are used to determine if someone has had a parvovirus infection in the past. This would be important if we wanted to determine whether a pregnant woman, for example, in contact with a fifth disease is immune or not. If the blood test shows that she has had a Parvovirus infection in the past then she is protected.

Treating the fifth disease

There are no available anti-viral medications that will treat the fifth disease nor can they be treated with antibiotics. Usually, children with the fifth disease feel fairly well and need little treatment other than rest. Acetaminophen (Tylenol or Tempra) may be recommended for fever or joint pain. At this time, there is no vaccine for the fifth disease.

When is the fifth disease contagious?

A child with a fifth disease is most contagious a few days before the rash appears. Note that a child is usually not contagious once the rash appears. Isolating a child with a fifth disease rash will not prevent the spread of the infection because the child usually is not contagious by that time.

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Pediatrician DR.PAUL Roumeliotis is certified by the American Board of Pediatrics and Royal College of Physicians and Surgeons of Canada. The information provided above is designed to be an educational aid only. It is not intended to replace the advice and care of your child’s physician, nor is it intended to be used for medical diagnosis or treatment. If you suspect that your child has a medical condition always consult a physician.